19 July 2013
Mitochondria in Aging and Disease
The course will cover a broad range of aspects of mitochondrial function and biology. It will introduce the students to the current knowledge on mitochondria metabolism and especially emphasize the involvement of mitochondrial dysfunction in disease processes like neurodegeneration, ischemia, diabetes, cancer, metabolic diseases as well as the aging process. The role of mitochondria in oxidative stress will be presented and mitochondrial maintenance mechanisms, mitochondrial dynamics, specific mitochondrial proteins and the mitochondrial proteome will be discussed. Finally, various methods for studying mitochondria and their functions will be presented and the applicability of the methods will be discussed.
Tinna V. Stevnsner, Aarhus University
Mitochondria are vital for providing cellular energy. Research in the last decade has shown that mitochondria play important roles in the maintenance of the nervous system, in a large number of human diseases and in aging. Thus, mitochondria are central to research into almost all aspects of the molecular biology of human life. The course will provide insight into the current knowledge about mitochondrial biology and its multifaceted roles in human health.
Qualification description / Learning outcomes and competences When the course has been completed the students are expected to be able to:
- Characterize mitochondria and their functions in general and relate this to their involvement in diseases and aging
- Discuss the role of mitochondria in cellular metabolism and growth control
- Relate metabolic diseases (fatty acid and amino acid metabolism, respiratory chain) to mitochondrial dysfunction
- Explain how mechanisms of mitochondrial involvement in diseases and aging can be studied and compare and discuss the limitations to the suggested methods and models
- Describe mitochondrial dynamics, biogenesis of mitochondrial proteins, mitochondrial protein quality control and mitochondrial genome maintenance.
- Judge mitochondrial proteome analyses
EUR 0: Students on a bilateral exchange programme do not have to pay. Freemovers are obliged to pay participation fees while tuition fees only apply to freemovers from countries outside the EU/EEA/Switzerland.