Netherlands, Nijmegen

How to Translate Basic Research into Clinical Applications: Lessons from the Eye

when 8 August 2016 - 12 August 2016
language English
duration 1 week
credits 2 ECTS
fee EUR 490

Do you want your research to make a difference and do you want to develop new treatments for devastating diseases? During this intensive one-week course you will be guided through all phases of translational research based on lessons we have learned from the eye. You will learn how to design studies to understand disease mechanisms and how to develop diagnostic tests and new treatments. You will learn about exciting new developments such as gene therapy trials that have restored vision in children.

The course is supported by the Donders Centre for Neurosciences. You will be taught by world leading experts specialised in translational research of diseases affecting the eye. The course will involve lectures as well as hands-on-experimental designs in the lab. You will learn to identify the genetic causes of inherited and multifactorial diseases which require different study designs. This will be illustrated by our research on retinal dystrophies, the most important cause of vision loss in children, and age-related macular degeneration, the most common cause of vision loss in the elderly You will learn how to model the molecular disease mechanisms using cellular model systems, including induced pluripotent stem cell (IPSC) technology and animal models as well. You will be taught how diagnostic and predictive tests can be developed for clinical applications and the challenges that are faced will be addressed. During the course, you will learn how knowledge of the molecular disease mechanisms can be translated towards the development of new treatments. Exciting new developments in the field of retinal dystrophies, such as gene therapy trials that have restored vision in blind children, will be highlighted during the course. Preclinical study designs, as well as challenges that are faced in the next step towards clinical translation of new treatments will be discussed.

The course is targeted at Bachelor students. Although the course is open to all levels of Bachelor, you can consider this course in particular if you are interested in joining one of the international life sciences research masters in 2017 or 2018, i.e. Molecular Mechanisms of Disease or Biomedical Sciences, or if you would like to perform an internship at a later stage within one of our departments. lt's a great chance to get to know us, and a great chance for us to get to know you!

Course leader

Dr. E. de Jong
Assistant Professor
Dept. of Ophthalmology/ Human Genetics

Target group

Bachelor students with a basic background in genetics and molecular biology.

Course aim

After this course you will be able to:
- Design studies to understand the molecular mechanisms underlying monogenic and multifactorial disease.
- Develop diagnostic/predictive tests for monogenic and multifactorial diseases.
- Select suitable model systems to study disease mechanisms and test new treatments.
- Design preclinical studies for developing new treatments.

Fee info

EUR 490: The course fee includes the registration fee, course materials, access to library and IT facilities, coffee/tea, lunch, and a number of social activities.

10% discount for early bird applicants. The early bird deadline is 1 April 2016.
15% discount for students and PhD candidates from Radboud University and partner universities.
EUR 195: Housing (optional)